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Programmed cell death ligand 1 expression associated with subtypes of post-transplant lymphoproliferative disorder among pediatric kidney transplant recipients.

Olga K WeinbergGeraldine C PinkusGabriel J Ramos-GonzalezTimna AgurNancy M Rodig
Published in: Clinical transplantation (2023)
In this case series, significant differences in PD-L1 expression were seen among different subtypes, and monomorphic PTLD demonstrated the highest expression. Study of a larger cohort is needed, and if the correlation of PD-L1 expression and PTLD subtype is confirmed, this may highlight the potential utility of checkpoint inhibitor therapy in cases of severe or refractory disease among kidney transplant recipient in whom the risk of allograft loss is acceptable given the option of chronic dialysis.
Keyphrases
  • poor prognosis
  • dna damage
  • chronic kidney disease
  • binding protein
  • cell cycle
  • stem cells
  • mesenchymal stem cells
  • cell proliferation
  • risk assessment
  • climate change
  • diffuse large b cell lymphoma
  • replacement therapy