Identifying potential patient-specific predictors for anterior cruciate ligament reconstruction outcome - a diagnostic in vitro tissue remodeling platform.

Marc van VijvenBart van GroningenJoyce N KimenaiMaria C van der SteenMarina van DoeselaarRob P A JanssenKeita ItoJasper Foolen

Published in: Journal of experimental orthopaedics (2020)

The presented micro-tissue platform exposed patient-specific remodeling-related differences between tendon-derived cells, with the micro-tissues that released from constraining posts and pro-collagen I expression best reflecting the clinical age-dependency of graft rupture. These properties can be the starting point in the quest for potential predictors for identifying individual patients at risk for graft rupture.

Keyphrases

anterior cruciate ligament reconstruction
end stage renal disease
induced apoptosis
high throughput
newly diagnosed
chronic kidney disease
ejection fraction
poor prognosis
gene expression
cell cycle arrest
cell death
signaling pathway
anti inflammatory
patient reported outcomes
climate change
single cell