Abnormal lymphatic S1P signaling aggravates lymphatic dysfunction and tissue inflammation.
Dongeon KimWen TianTimothy Ting-Hsuan WuMenglan XiangRyan VinhJason Lon ChangShenbiao GuSeunghee LeeYu ZhuTorrey GuanEmilie Claire SchneiderEvan BaoJ Brandon DixonPeter N KaoJunliang PanStanley G RocksonXinguo JiangMark Robert NicollsPublished in: medRxiv : the preprint server for health sciences (2023)
S1P/S1PR1 signaling in LECs regulates inflammation in lymphedema tissue.S1PR1 expression levels on LECs may be a useful biomarker for assessing predisposition to lymphatic disease, such as at-risk women undergoing mastectomyP-selectin Inhibitors may be effective for certain forms of lymphedema.