Analysis of the structure and function of the epidermal barrier in patients with ichthyoses-clinical and electron microscopical investigations.
Regina Fölster-HolstC NaßS Dähnhardt-PfeifferS Freitag-WolfPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)
The results demonstrate the extent of the epidermal barrier disruption in ichthyoses. In combination with the knowledge about pathogenetic causes, individually improved therapeutic options can be derived from our results. In the future, the analyses of the organization of intercellular lipid lamellae and corneocyte membrane undulation will enable improved investigations of the epidermal barrier in ichthyoses and may be used to study and evaluate possible effects of topical skin preparations.