Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes.

Xueqi CaoSandra HuberAta Jadid AhariFranziska R TraubeMarc SeifertChristopher C OakesPolina SecheykoSergey Vilov Ines F SchellerNils WagnerVicente A YépezPiers BlomberyTorsten HaferlachMatthias Heinig Leonhard WachutkaStephan HutterJulien Gagneur

Published in: Genome medicine (2024)

Altogether, our census of expression and splicing outliers for 24 hematologic malignancy entities and the companion computational workflow constitute unique resources to deepen our understanding of rare oncogenic events in hematologic cancers.

Keyphrases

poor prognosis
genome wide
single cell
transcription factor
copy number
binding protein
rna seq
gene expression
electronic health record
dna methylation
childhood cancer