AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer.

Mauricio Marquez-Palencia Luis Reza Herrera Pravat Kumar Parida Suvranil Ghosh Kangsan Kim Nikitha M Das Paula I Gonzalez Ericsson Melinda E Sanders Bret C Mobley Sebastian Diegeler Todd A Aguilera Yan Peng Cheryl M Lewis Carlos L Arteaga Ariella B Hanker Angelique W Whitehurst James B Lorens Rolf A Brekken Anthony J Davis Srinivas Malladi

Published in: Cancer research (2024)

Nuclear AXL and WRNIP1 interact and mediate replication stress response, promote therapy resistance, and support metastatic progression, indicating that targeting the AXL/WRNIP1 axis is a potentially viable therapeutic strategy for breast cancer.

Keyphrases

tyrosine kinase
squamous cell carcinoma
small cell lung cancer
young adults
cell therapy
smoking cessation