Rolf A Brekken (Rolf Brekken)

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 49

Top Topics

Small Cell Lung Cancer

Extracellular Matrix

Top Venues

Nature communications

Cancer research

The Journal of experimental medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Mauricio Marquez-Palencia, Luis Reza Herrera, Pravat Kumar Parida, Suvranil Ghosh, Kangsan Kim, Nikitha M Das, Paula I Gonzalez Ericsson, Melinda E Sanders, Bret C Mobley, Sebastian Diegeler, Todd A Aguilera, Yan Peng, Cheryl M Lewis, Carlos L Arteaga, Ariella B Hanker, Angelique W Whitehurst, James B Lorens, Rolf A Brekken, Anthony J Davis, Srinivas Malladi
AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer. Cancer research 84 (5) (2024)
David Hsiehchen, Muhammad S Beg, Radhika Kainthla, Jay Lohrey, Syed M Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A Brekken, Chul Ahn, Amit G Singal, Hao Zhu, Yujin Hoshida, Adam C Yopp
The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial. Nature communications 15 (1) (2024)
Mauricio Marquez-Palencia, Luis Reza Herrera, Pravat Kumar Parida, Suvranil Ghosh, Kangsan Kim, Nikitha M Das, Paula I Gonzalez Ericsson, Melinda E Sanders, Bret C Mobley, Sebastian Diegeler, Todd A Aguilera, Yan Peng, Cheryl M Lewis, Carlos L Arteaga, Ariella B Hanker, Angelique W Whitehurst, James B Lorens, Rolf A Brekken, Anthony J Davis, Srinivas Malladi
AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer. Cancer research 84 (5) (2024)
Lulu Wang, Alan H Zhao, Chad A Arledge, Fei Xing, Michael D Chan, Rolf A Brekken, Amyn A Habib, Dawen Zhao
Exposed Phosphatidylserine as a Biomarker for Clear Identification of Breast Cancer Brain Metastases in Mouse Models. Cancers 16 (17) (2024)
David Hsiehchen, Muhammad S Beg, Radhika Kainthla, Jay Lohrey, Syed M Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A Brekken, Chul Ahn, Amit G Singal, Hao Zhu, Yujin Hoshida, Adam C Yopp
The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial. Nature communications 15 (1) (2024)
David Hsiehchen, Muhammad S Beg, Radhika Kainthla, Jay Lohrey, Syed M Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A Brekken, Chul Ahn, Amit G Singal, Hao Zhu, Yujin Hoshida, Adam C Yopp
The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial. Nature communications 15 (1) (2024)
David Hsiehchen, Muhammad S Beg, Radhika Kainthla, Jay Lohrey, Syed M Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A Brekken, Chul Ahn, Amit G Singal, Hao Zhu, Yujin Hoshida, Adam C Yopp
The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial. Nature communications 15 (1) (2024)
Mauricio Marquez-Palencia, Luis Reza Herrera, Pravat Kumar Parida, Suvranil Ghosh, Kangsan Kim, Nikitha M Das, Paula I Gonzalez Ericsson, Melinda E Sanders, Bret C Mobley, Sebastian Diegeler, Todd A Aguilera, Yan Peng, Cheryl M Lewis, Carlos L Arteaga, Ariella B Hanker, Angelique W Whitehurst, James B Lorens, Rolf A Brekken, Anthony J Davis, Srinivas Malladi
AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer. Cancer research 84 (5) (2024)
Havish S Kantheti, Michael A Hale, Shreoshi Pal Choudhuri, Huocong Huang, Xu-Dong Wang, Yalda Zolghadri, Giulio Innamorati, Sai Prasada Rao Manikonda, Naviya Reddy, Sarthak Reddy, Rahul K Kollipara, Valbona Lumani, Luc Girard, Yakov Bezrukov, Pavel S Demenkov, Raymond J MacDonald, Rolf A Brekken, Yonghao Yu, Thomas M Wilkie
Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma. International journal of molecular sciences 25 (12) (2024)
Mauricio Marquez-Palencia, Luis Reza Herrera, Pravat Kumar Parida, Suvranil Ghosh, Kangsan Kim, Nikitha M Das, Paula I Gonzalez Ericsson, Melinda E Sanders, Bret C Mobley, Sebastian Diegeler, Todd A Aguilera, Yan Peng, Cheryl M Lewis, Carlos L Arteaga, Ariella B Hanker, Angelique W Whitehurst, James B Lorens, Rolf A Brekken, Anthony J Davis, Srinivas Malladi
AXL/WRNIP1 Mediates Replication Stress Response and Promotes Therapy Resistance and Metachronous Metastasis in HER2+ Breast Cancer. Cancer research 84 (5) (2024)
Havish S Kantheti, Michael A Hale, Shreoshi Pal Choudhuri, Huocong Huang, Xu-Dong Wang, Yalda Zolghadri, Giulio Innamorati, Sai Prasada Rao Manikonda, Naviya Reddy, Sarthak Reddy, Rahul K Kollipara, Valbona Lumani, Luc Girard, Yakov Bezrukov, Pavel S Demenkov, Raymond J MacDonald, Rolf A Brekken, Yonghao Yu, Thomas M Wilkie
Diagnostic and Prognostic Markers for Pancreatitis and Pancreatic Ductal Adenocarcinoma. International journal of molecular sciences 25 (12) (2024)
Mauricio Marquez-Palencia, Luis Reza Herrera, Pravat Kumar Parida, Suvranil Ghosh, Kangsan Kim, Nikitha M Das, Paula I Gonzalez Ericsson, Melinda E Sanders, Bret C Mobley, Sebastian Diegeler, Todd A Aguilera, Yan Peng, Cheryl M Lewis, Carlos L Arteaga, Ariella B Hanker, Angelique W Whitehurst, James B Lorens, Rolf A Brekken, Anthony J Davis, Srinivas Malladi
AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer. Cancer research (2024)
David Hsiehchen, Muhammad S Beg, Radhika Kainthla, Jay Lohrey, Syed M Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A Brekken, Chul Ahn, Amit G Singal, Hao Zhu, Yujin Hoshida, Adam C Yopp
The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial. Nature communications 15 (1) (2024)
Debolina Ganguly, Marcel O Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T A Dominguez, Gilbert Z Murimwa, Jason E Toombs, Cheryl M Lewis, Yisheng V Fang, Fatima Valdes Mora, David Gallego Ortega, Anton Wellstein, Rolf A Brekken
Pleiotrophin drives a prometastatic immune niche in breast cancer. The Journal of experimental medicine 220 (5) (2023)
Debolina Ganguly, Marcel O Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T A Dominguez, Gilbert Z Murimwa, Jason E Toombs, Cheryl M Lewis, Yisheng V Fang, Fatima Valdes Mora, David Gallego Ortega, Anton Wellstein, Rolf A Brekken
Pleiotrophin drives a prometastatic immune niche in breast cancer. The Journal of experimental medicine 220 (5) (2023)
Debolina Ganguly, Marcel O Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T A Dominguez, Gilbert Z Murimwa, Jason E Toombs, Cheryl M Lewis, Yisheng V Fang, Fatima Valdes Mora, David Gallego Ortega, Anton Wellstein, Rolf A Brekken
Pleiotrophin drives a prometastatic immune niche in breast cancer. The Journal of experimental medicine 220 (5) (2023)
Debolina Ganguly, Marcel O Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T A Dominguez, Gilbert Z Murimwa, Jason E Toombs, Cheryl M Lewis, Yisheng V Fang, Fatima Valdes Mora, David Gallego Ortega, Anton Wellstein, Rolf A Brekken
Pleiotrophin drives a prometastatic immune niche in breast cancer. The Journal of experimental medicine 220 (5) (2023)
Debolina Ganguly, Marcel O Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T A Dominguez, Gilbert Z Murimwa, Jason E Toombs, Cheryl M Lewis, Yisheng V Fang, Fatima Valdes Mora, David Gallego Ortega, Anton Wellstein, Rolf A Brekken
Pleiotrophin drives a prometastatic immune niche in breast cancer. The Journal of experimental medicine 220 (5) (2023)
Krystal C Johnson, Audrius Kilikevicius, Cristina Hofman, Jiaxin Hu, Yang Liu, Selina Aguilar, Jon Graswich, Yi Han, Tao Wang, Jill M Westcott, Rolf A Brekken, Lan Peng, Georgios Karagkounis, David R Corey
Nuclear Localization of Argonaute is affected by Cell Density and May Relieve Repression by microRNAs. bioRxiv : the preprint server for biology (2023)
Debolina Ganguly, Marcel O Schmidt, Morgan Coleman, Tuong-Vi Cindy Ngo, Noah Sorrelle, Adrian T A Dominguez, Gilbert Z Murimwa, Jason E Toombs, Cheryl M Lewis, Yisheng V Fang, Fatima Valdes Mora, David Gallego Ortega, Anton Wellstein, Rolf A Brekken
Pleiotrophin drives a prometastatic immune niche in breast cancer. The Journal of experimental medicine 220 (5) (2023)
Lufei Sui, Suming Wang, Debolina Ganguly, Tyler P El Rayes, Cecilie Askeland, Astrid Børretzen, Danielle Sim, Ole Johan Halvorsen, Gøril Knutsvik, Jarle Arnes, Sura Aziz, Svein Haukaas, William D Foulkes, Diane R Bielenberg, Arturas Ziemys, Vivek Mittal, Rolf A Brekken, Lars A Akslen, Randolph S Watnick
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nature communications 13 (1) (2022)
Lufei Sui, Suming Wang, Debolina Ganguly, Tyler P El Rayes, Cecilie Askeland, Astrid Børretzen, Danielle Sim, Ole Johan Halvorsen, Gøril Knutsvik, Jarle Arnes, Sura Aziz, Svein Haukaas, William D Foulkes, Diane R Bielenberg, Arturas Ziemys, Vivek Mittal, Rolf A Brekken, Lars A Akslen, Randolph S Watnick
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nature communications 13 (1) (2022)
Lufei Sui, Suming Wang, Debolina Ganguly, Tyler P El Rayes, Cecilie Askeland, Astrid Børretzen, Danielle Sim, Ole Johan Halvorsen, Gøril Knutsvik, Jarle Arnes, Sura Aziz, Svein Haukaas, William D Foulkes, Diane R Bielenberg, Arturas Ziemys, Vivek Mittal, Rolf A Brekken, Lars A Akslen, Randolph S Watnick
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nature communications 13 (1) (2022)
Lufei Sui, Suming Wang, Debolina Ganguly, Tyler P El Rayes, Cecilie Askeland, Astrid Børretzen, Danielle Sim, Ole Johan Halvorsen, Gøril Knutsvik, Jarle Arnes, Sura Aziz, Svein Haukaas, William D Foulkes, Diane R Bielenberg, Arturas Ziemys, Vivek Mittal, Rolf A Brekken, Lars A Akslen, Randolph S Watnick
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nature communications 13 (1) (2022)
Yuqing Zhang, Rolf A Brekken
Are TEMs Canceled? Questioning the Functional Relevance of Tie2-Expressing Macrophages. Cancer research 82 (7) (2022)
Kangsan Kim, Huocong Huang, Pravat Kumar Parida, Lan He, Mauricio Marquez-Palencia, Tanner C Reese, Payal Kapur, James Brugarolas, Rolf A Brekken, Srinivas Malladi
Cell Competition Shapes Metastatic Latency and Relapse. Cancer discovery (2022)
Lufei Sui, Suming Wang, Debolina Ganguly, Tyler P El Rayes, Cecilie Askeland, Astrid Børretzen, Danielle Sim, Ole Johan Halvorsen, Gøril Knutsvik, Jarle Arnes, Sura Aziz, Svein Haukaas, William D Foulkes, Diane R Bielenberg, Arturas Ziemys, Vivek Mittal, Rolf A Brekken, Lars A Akslen, Randolph S Watnick
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nature communications 13 (1) (2022)
Yuqing Zhang, Morgan Coleman, Rolf A Brekken
Perspectives on Hypoxia Signaling in Tumor Stroma. Cancers 13 (12) (2021)
Ravikanth Maddipati, Robert J Norgard, Timour Baslan, Komal S Rathi, Amy Zhang, Asal Saeid, Taku Higashihara, Feng Wu, Angad Kumar, Valli Annamalai, Saurav Bhattacharya, Pichai Raman, Christian A Adkisson, Jason R Pitarresi, Maximilian D Wengyn, Taiji Yamazoe, Jinyang Li, David Balli, Michael J LaRiviere, Tuong-Vi Cindy Ngo, Ian W Folkert, Ian Daniel Millstein, Jonathan Bermeo, Erica L Carpenter, John C McAuliffe, Maja H Oktay, Rolf A Brekken, Scott W Lowe, Christine A Iacobuzio-Donahue, Faiyaz Notta, Ben Z Stanger
MYC levels regulate metastatic heterogeneity in pancreatic adenocarcinoma. Cancer discovery (2021)
David Calianese, Tamara Kreiss, Canan Kasikara, Viralkumar Davra, Kevin C Lahey, Varsha Gadiyar, Ke Geng, Sukhwinder Singh, William Honnen, Dabbu Kumar Jaijyan, Charles Reichman, John Siekierka, Maria Laura Gennaro, Sergei V Kotenko, David S Ucker, Rolf A Brekken, Abraham Pinter, Raymond B Birge, Alok Choudhary
Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28-Stimulated T Cell IFN-γ and TNF-α Production. Journal of immunology (Baltimore, Md. : 1950) 207 (2) (2021)
Huocong Huang, Rolf A Brekken
Location Matters: Profiling Diffuse Type Gastric Cancer At the Single-Cell Level. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (23) (2021)
Wenting Du, Natalie Z Phinney, Huocong Huang, Zhaoning Wang, Jill Westcott, Jason E Toombs, Yuqing Zhang, Muhammad Shaalan Beg, Thomas M Wilkie, James B Lorens, Rolf A Brekken
AXL Is a Key Factor for Cell Plasticity and Promotes Metastasis in Pancreatic Cancer. Molecular cancer research : MCR 19 (8) (2021)
Cara Ellen Wogsland, Hilde E Lien, Line Pedersen, Pahul Hanjra, Sturla Magnus Grøndal, Rolf A Brekken, James B Lorens, Nils Halberg
High-dimensional immunotyping of tumors grown in obese and non-obese mice. Disease models & mechanisms 14 (4) (2021)
Raghav Chandra, John D Karalis, Charles Ruohua Liu, Gilbert Z Murimwa, Josiah Voth Park, Christopher A Heid, Scott I Reznik, Emina H Huang, John D Minna, Rolf A Brekken
The Colorectal Cancer Tumor Microenvironment and Its Impact on Liver and Lung Metastasis. Cancers 13 (24) (2021)
Yuqing Zhang, Emily N Arner, Ali Rizvi, Jason E Toombs, Huocong Huang, Steven L Warner, Jason M Foulks, Rolf A Brekken
AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer. Molecular cancer therapeutics (2021)
Shivani Malik, Jill M Westcott, Rolf A Brekken, Francis J Burrows
CXCL12 in Pancreatic Cancer: Its Function and Potential as a Therapeutic Drug Target. Cancers 14 (1) (2021)
Abdel N Hosein, Rolf A Brekken, Anirban Maitra
Pancreatic cancer stroma: an update on therapeutic targeting strategies. Nature reviews. Gastroenterology & hepatology 17 (8) (2020)
Huocong Huang, Rolf A Brekken
Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer. American journal of physiology. Cell physiology 319 (2) (2020)
Adam S Dayoub, Rolf A Brekken
TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy. Cell communication and signaling : CCS 18 (1) (2020)
Jill M Westcott, Sharon Camacho, Apsra Nasir, Molly E Huysman, Raneen Rahhal, Tuyen T Dang, Anna T Riegel, Rolf A Brekken, Gray W Pearson
ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader-Follower Relationship That Drives Collective Invasion. Cancer research 80 (18) (2020)
Andrew S Chung, Marcel Mettlen, Debolina Ganguly, Tianshi Lu, Tao Wang, Rolf A Brekken, David Hsiehchen, Hao Zhu
Immune Checkpoint Inhibition is Safe and Effective for Liver Cancer Prevention in a Mouse Model of Hepatocellular Carcinoma. Cancer prevention research (Philadelphia, Pa.) 13 (11) (2020)
David E Gerber, William C Putnam, Farjana J Fattah, Kemp H Kernstine, Rolf A Brekken, Ivan Pedrosa, Rachael Skelton, Jessica M Saltarski, Robert E Lenkinski, Richard D Leff, Chul Ahn, Chyndhri Padmanabhan, Vaidehi Chembukar, Sahba Kasiri, Raja Reddy Kallem, Indhumathy Subramaniyan, Qing Yuan, Quyen N Do, Yin Xi, Scott I Reznik, Lorraine Pelosof, Brandon Faubert, Ralph J DeBerardinis, James Kim
Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (22) (2020)
Huocong Huang, Yuqing Zhang, Valerie Gallegos, Noah Sorrelle, Mohamed Medhat Zaid, Jason Toombs, Wenting Du, Steven Wright, Moriah Hagopian, Zhaoning Wang, Abdel Nasser Hosein, Adwait Amod Sathe, Chao Xing, Eugene J Koay, Kyla E Driscoll, Rolf A Brekken
Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer. EMBO molecular medicine 11 (11) (2019)
Karoliina Stefanius, Kelly A Servage, Marcela de Souza Santos, Hillery Fields Gray, Jason E Toombs, Suneeta Chimalapati, Min S Kim, Venkat S Malladi, Rolf A Brekken, Kim Orth
Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation. eLife 8 (2019)
Ileana C Cuevas, Subhransu S Sahoo, Ashwani Kumar, He Zhang, Jill Westcott, Mitzi Aguilar, Jeremy D Cortez, Stephanie A Sullivan, Chao Xing, D Neil Hayes, Rolf A Brekken, Victoria L Bae-Jump, Diego H Castrillon
Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition. Proceedings of the National Academy of Sciences of the United States of America 116 (51) (2019)
Xinqun Li, Yeonju Lee, Ya'an Kang, Bingbing Dai, Mayrim V Rios Perez, Michael Pratt, Eugene Jon Koay, Michael Kim, Rolf A Brekken, Jason B Fleming
Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma. Cell death and differentiation 26 (2) (2018)
Noah Sorrelle, Debolina Ganguly, Adrian T A Dominguez, Yuqing Zhang, Huocong Huang, Lekh N Dahal, Natalie Z Phinney, Arturas Ziemys, Rolf A Brekken
Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues. Journal of immunology (Baltimore, Md. : 1950) 202 (1) (2018)
Xiaofeng Wu, Li-Shu Zhang, Jason Toombs, Yi-Chun Kuo, John Tyler Piazza, Rubina Tuladhar, Quinn Barrett, Chih-Wei Fan, Xuewu Zhang, Loren D Walensky, Marcel Kool, Steven Y Cheng, Rolf A Brekken, Joseph T Opferman, Douglas R Green, Tudor Moldoveanu, Lawrence Lum
Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nature cell biology 19 (10) (2017)
Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A Brekken, Bruce A Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A Wheeler, John D Minna, Michael A White, Adi F Gazdar, Michael G Roth
SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers. Nature communications 8 (2017)