Deoxycholic acid enhancement of lymphocyte migration through direct interaction with the intestinal vascular endothelium.
Naoki ShibuyaMasaaki HigashiyamaYoshihiro AkitaKazuhiko ShirakabeSuguru ItoShin NishiiAkinori MizoguchiKenichi InabaRina TanemotoNao SugiharaYoshinori HanawaAkinori WadaKazuki HoriuchiKenichi YoshikawaChie KuriharaYoshikiyo OkadaChikako WatanabeShunsuke KomotoKengo TomitaMasayuki SarutaRyota HokariPublished in: Journal of gastroenterology and hepatology (2021)
DCA exacerbated IND-induced small intestinal enteropathy. DCA directly acts on the vascular endothelium and enhances the expression levels of adhesion molecules partially via S1PR2, leading to enhanced small intestinal lymphocyte migration.