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Impact of BCL-2 Expression on Course of Disease in Neuroblastoma.

Jakob MuehlingAlexandra Fröba-PohlOliver J MuenstererDietrich von SchweinitzRoland Kappler
Published in: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie (2023)
 Our study demonstrates the ubiquitous expression of BCL-2 in neuroblastoma and suggests the possibility for targeted therapy with BCL-2 inhibitors, even in lower-stage neuroblastoma. It also underlines the need for further research on concomitant genetic alterations for a better understanding of the impact of BCL-2 on this pediatric tumor type.
Keyphrases
  • poor prognosis
  • binding protein
  • gene expression
  • young adults
  • dna methylation