Impact of BCL-2 Expression on Course of Disease in Neuroblastoma.
Jakob MuehlingAlexandra Fröba-PohlOliver J MuenstererDietrich von SchweinitzRoland KapplerPublished in: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie (2023)
Our study demonstrates the ubiquitous expression of BCL-2 in neuroblastoma and suggests the possibility for targeted therapy with BCL-2 inhibitors, even in lower-stage neuroblastoma. It also underlines the need for further research on concomitant genetic alterations for a better understanding of the impact of BCL-2 on this pediatric tumor type.