NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH.
Jonathan G StineIan R SchreibmanAlison J FaustJessica DahmusBenjamin SternChristopher SorianoGloriany RivasBreianna HummerScot R KimballNathaniel R GeyerVernon M ChinchilliRohit L LoombaKathryn SchmitzChristopher SciamannaPublished in: Hepatology (Baltimore, Md.) (2021)
This clinical trial showed that independent of weight loss or dietary change, exercise training resulted in a significantly greater decrease in thrombotic risk than standard clinical care in patients with NASH, in parallel with MRI-PDFF reduction and improvement in fitness. Future studies are required to determine if exercise training can directly impact patient outcomes and lower rates of thromboembolism.