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Sodium and urea excretion as determinants of urine output in autosomal dominant polycystic kidney disease patients on V2 receptor antagonists: impact of dietary intervention.

Gabrielle CôtéLori Asselin-ThompstoneFabrice Mac-WayPaul René de CotretChristine LacroixSimon DesmeulesMohsen Agharazii
Published in: International urology and nephrology (2020)
Both sodium and urea excretion rates contribute significantly to daily urine volume in patients treated with tolvaptan, and a single session of dietary counseling was transiently effective in reducing sodium intake but achieved a more sustained reduction in protein intake. Dietary counseling should be considered in the management of ADPKD patients treated by tolvaptan.
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