Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats.

Marina VilasecaHéctor García-CalderóErica LafozMaria RuartCristina Isabel López-SanjurjoMichael P MurphyRamon DeulofeuJaume BoschVirginia Hernández-GeaJordi Gracia-SanchoJoan Carles García-Pagán

Published in: Liver international : official journal of the International Association for the Study of the Liver (2017)

We propose mitochondria-targeted antioxidants as a novel treatment approach against portal hypertension and cirrhosis.

Keyphrases

blood pressure
induced apoptosis
cell death
oxidative stress
endothelial cells
cancer therapy
cell cycle arrest
reactive oxygen species
endoplasmic reticulum
induced pluripotent stem cells
pluripotent stem cells
signaling pathway
combination therapy
endoplasmic reticulum stress