Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model.
Jang-Woon KimJuryun KimSoon Min LeeYeri Alice RimYoung Chul SungYoojun NamHyo-Jin KimHyewon KimSe In JungJooyoung LimJi Hyeon JuPublished in: Stem cell research & therapy (2024)
Our results suggest that the combined transplantation of BDNF- eMSC and iMNP in chronic SCI results in a significant clinical recovery. The transplanted iMNP cells predominantly differentiated into mature motor neurons. Additionally, BDNF-eMSC exerts a paracrine effect on neuron regeneration through BDNF expression in the injured spinal cord.
Keyphrases
- spinal cord injury
- spinal cord
- mesenchymal stem cells
- stem cells
- neuropathic pain
- stress induced
- induced apoptosis
- poor prognosis
- drug induced
- diabetic rats
- cell cycle arrest
- cell therapy
- high glucose
- bone marrow
- wound healing
- endoplasmic reticulum stress
- oxidative stress
- cell proliferation
- african american
- optic nerve