Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the Mucor species complex.
Maria Isabel Navarro-MendozaCarlos Pérez-ArquesJosie E ParkerSteven L KellyJoseph HeitmanPublished in: bioRxiv : the preprint server for biology (2023)
mutants survive within the host and disseminate the infection, indicating that Erg6a deficiency may arise during human infections and confer resistance to the most effective treatment against mucormycoses.