Impact of Arterial Input Function and Pharmacokinetic Models on DCE-MRI Biomarkers for Detection of Vascular Effect Induced by Stroma-Directed Drug in an Orthotopic Mouse Model of Pancreatic Cancer.

Jianbo CaoStephen PickupMark RosenRong Zhou

Published in: Molecular imaging and biology (2023)

from ETM, both using group AIF, are optimal for the detection of microvascular changes induced by stroma-directed drug PEGPH20. These analyses provide insights in the choice of PK model and AIF for optimal DCE protocol design in mouse pancreatic cancer models.

Keyphrases

contrast enhanced
mouse model
loop mediated isothermal amplification
magnetic resonance imaging
label free
randomized controlled trial
real time pcr
emergency department
drug induced
magnetic resonance
adverse drug
diffusion weighted imaging