The effect of two drug delivery systems in ropivacaine cytotoxicity and cytokine release by human keratinocytes and fibroblasts.

Luiz Eduardo Nunes FerreiraBruno Vilela MunizJonny Burga-SánchezMaria Cristina VolpatoEneida de PaulaEdvaldo Antonio Ribeiro RosaFrancisco Carlos Groppo

Published in: The Journal of pharmacy and pharmacology (2016)

The loss in cell viability was not related to cellular apoptosis. Ropi complexed with HP-β-CD showed a similar cytokine release pattern when compared to the plain formulation. Thus, the HP-β-CD form was a better drug carrier than the MLV form for ropivacaine drug delivery.

Keyphrases

drug delivery
endothelial cells
postoperative pain
cancer therapy
endoplasmic reticulum stress
nk cells
cell death
cell cycle arrest
induced pluripotent stem cells
drug induced
emergency department
extracellular matrix
pluripotent stem cells
wound healing