The effect of two drug delivery systems in ropivacaine cytotoxicity and cytokine release by human keratinocytes and fibroblasts.
Luiz Eduardo Nunes FerreiraBruno Vilela MunizJonny Burga-SánchezMaria Cristina VolpatoEneida de PaulaEdvaldo Antonio Ribeiro RosaFrancisco Carlos GroppoPublished in: The Journal of pharmacy and pharmacology (2016)
The loss in cell viability was not related to cellular apoptosis. Ropi complexed with HP-β-CD showed a similar cytokine release pattern when compared to the plain formulation. Thus, the HP-β-CD form was a better drug carrier than the MLV form for ropivacaine drug delivery.