Effect of GBA gene variants on clinical characteristics of dementia with Lewy bodies: a review and meta-analyses.

Li LiuJia LiWei QuanYidan QinQinghui ZhangXiaochen PeiHang SuJing XuJiajun Chen

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)

GBA variants increased the risk of DLB, especially N370S, E326K, and L444P which are strongly associated with DLB, but T369M was not. Patients harbouring GBA variants have an earlier age of onset, more severe cognitive impairment, and rapid symptom progression; however, sex is irrelevant in DLB.

Keyphrases

copy number
cognitive impairment
meta analyses
end stage renal disease
systematic review
ejection fraction
newly diagnosed
genome wide
prognostic factors
randomized controlled trial
early onset
patient reported
parkinson disease
patient reported outcomes
dna methylation
transcription factor