Inhibition of phosphodiesterase-4 in the spinal dorsal horn ameliorates neuropathic pain via cAMP-cytokine-Cx43 signaling in mice.

Fang-Fang ZhangHao WangYan-Meng ZhouHai-Yang YuMelanie ZhangXian DuDong WangFeng ZhangYing XuJi-Guo ZhangHan-Ting Zhang

Published in: CNS neuroscience & therapeutics (2022)

The results suggest that the antinociceptive effect of PDE4 inhibitors is contributed by increasing Cx43 expression via cAMP-PKA-cytokine signaling in the spinal dorsal horn.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
binding protein
poor prognosis
mouse model
protein kinase
metabolic syndrome
adipose tissue
anti inflammatory