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Oiling the wheels of nuclear division: SUMOylation regulates the expansion of the mitotic nuclear membrane.

Symeon Siniossoglou
Published in: The Journal of cell biology (2023)
Eukaryotic cell division involves the segregation of chromosomes between two daughter cells and must be coordinated with extensive rearrangement of their nuclear envelopes. In this issue, Saik et al. (2023 J. Cell Biol. https://doi.org/10.1083/jcb.202208137) show that a SUMOylation cascade at the inner nuclear membrane elevates the levels of phosphatidic acid, a key phospholipid precursor, to support the need for nuclear membrane expansion during mitosis.
Keyphrases
  • single cell
  • cell therapy
  • induced apoptosis
  • stem cells
  • oxidative stress
  • cell cycle arrest
  • fatty acid