Performance of serum neurofilament light chain in a wide spectrum of clinical courses of amyotrophic lateral sclerosis - a cross-sectional multicenter study.
Thomas MeyerErma SalkicTorsten GrehlUte WeyenDagmar KettemannPatrick WeydtRene GüntherPaul LingorJan Christoph KochSusanne PetriAndreas HermannJohannes PrudloJulian GroßkreutzPetra BaumMatthias BoentertMoritz MetelmannJenny NordenIsabell CordtsJochen H WeishauptJohannes DorstAlbert LudolphYasemin KocBertram WalterChristoph MünchSusanne SpittelMarie DregerAndré MaierPéter KörtvélyessyPublished in: European journal of neurology (2023)
The finding of moderate sNfL elevation in patients with long ALS duration underlined the favorable prognosis of low sNfL. The strong correlation of sNfL Z score with ALS-PR strengthened its value as progression marker in clinical management and research. The lowering of sNfL in correlation with long TIV duration could reflect either a reduction in disease activity or in the neuroaxonal substrate of biomarker formation during the protracted course of ALS.