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Tethered IL15-IL15Rα augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse model.

Inés Sánchez-MorenoAritz Lasarte-CiaCelia Martín-OtalNoelia CasaresFlor NavarroMarta GorraizPatricia SarriónSandra Hervás-StubbsLorea JordanaJuan Roberto Rodriguez-MadozJesús San MiguelFelipe ProsperJuan Jose LasarteTeresa Lozano
Published in: Journal for immunotherapy of cancer (2024)
Tethered IL15-IL15Rα augments the antitumor activity of CD19 CAR-T cells but displays long-term toxicity in immunocompetent mice. Inducible systems to regulate IL15-IL15Rα expression could be considered to control this toxicity.
Keyphrases
  • mouse model
  • oxidative stress
  • poor prognosis
  • type diabetes
  • metabolic syndrome
  • insulin resistance