Tethered IL15-IL15Rα augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse model.
Inés Sánchez-MorenoAritz Lasarte-CiaCelia Martín-OtalNoelia CasaresFlor NavarroMarta GorraizPatricia SarriónSandra Hervás-StubbsLorea JordanaJuan Roberto Rodriguez-MadozJesús San MiguelFelipe ProsperJuan Jose LasarteTeresa LozanoPublished in: Journal for immunotherapy of cancer (2024)
Tethered IL15-IL15Rα augments the antitumor activity of CD19 CAR-T cells but displays long-term toxicity in immunocompetent mice. Inducible systems to regulate IL15-IL15Rα expression could be considered to control this toxicity.