Targeted delivery of doxorubicin to cancer cells by a cruciform DNA nanostructure composed of AS1411 and FOXM1 aptamers.
Khalil AbnousNoor Mohammad DaneshMohammad RamezaniFahimeh CharbgooAmirhossein BahreyniSeyed Mohammad TaghdisiPublished in: Expert opinion on drug delivery (2018)
These findings confirmed that synergistic combination of FOXM1 aptamer and Dox into Dox-DNA nanostructure complex enhanced antitumor effectiveness and reduced toxicity toward nontarget cells, opening up new insights in cancer treatment.
Keyphrases
- circulating tumor
- induced apoptosis
- nucleic acid
- cell free
- single molecule
- cancer therapy
- cell cycle arrest
- randomized controlled trial
- oxidative stress
- gold nanoparticles
- systematic review
- drug delivery
- endoplasmic reticulum stress
- sensitive detection
- cell death
- circulating tumor cells
- cell proliferation
- quantum dots