Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells.

Hyung Joon Kim Mi Kyung Gong Cheol Yong Yoon Jaeku Kang Mijin Yun Nam-Hoon Cho Sun Young Rha Young Deuk Choi

Published in: Yonsei medical journal (2020)

HSP90 inhibitor monotherapy and in combination with the PI3K/mTOR survival pathway inhibitor NVP-BEZ235 shows a synergistic antitumor effect in cisplatin-resistant bladder cancers, eliciting cell cycle arrest at the G1 phase and induction of caspase-dependent apoptotic pathway.

Keyphrases

cell cycle arrest
cell death
induced apoptosis
heat shock protein
endothelial cells
pi k akt
cell proliferation
spinal cord injury
heat stress
heat shock
cancer therapy
randomized controlled trial
endoplasmic reticulum stress
induced pluripotent stem cells