Photon and Proton irradiation in Patient-derived, Three-Dimensional Soft Tissue Sarcoma Models.

Siyer RoohaniJürgen LoskutovJens HeufelderFelix EhretLena WedekenManuela RegenbrechtRica SauerDaniel ZipsAndrea DenkerAntonia M JoussenChristian R A RegenbrechtDavid Kaul

Published in: BMC cancer (2023)

Pronounced differences in radiosensitivity are evident among UPS and PLS 3D patient-derived sarcoma cell cultures which may reflect the clinical heterogeneity. Photon and proton radiation showed similar dose-dependent cell-killing effectiveness in both 3D cell cultures. Patient-derived 3D STS cell cultures may represent a valuable tool to enable translational studies towards individualized subtype-specific radiotherapy in patients with STS.

Keyphrases

single cell
randomized controlled trial
systematic review
radiation induced
bone marrow
early stage
locally advanced
living cells