Effect of Concomitant Benzodiazepine Use on Efficacy and Safety of Esketamine Nasal Spray in Patients with Major Depressive Disorder and Acute Suicidal Ideation or Behavior: Pooled Randomized, Controlled Trials.

Bettina DiekampStephane BorentainDong-Jing FuRobert MurrayKristin HeerleinQiaoyi ZhangCornelius SchüleMaju Mathews

Published in: Neuropsychiatric disease and treatment (2021)

Benzodiazepines do not meaningfully affect the rapid-acting antidepressant effect of esketamine at 24 hours post-first dose among patients with MDD and acute suicidal ideation or behavior.

Keyphrases

major depressive disorder
bipolar disorder
liver failure
respiratory failure
randomized controlled trial
drug induced
aortic dissection
clinical trial
study protocol
open label