Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function.
Weiyi XuCyrielle BillonHui LiAndrea WildermanLei QiAndrea GravesJernie Rae Dela Cruz RidebYuanbiao ZhaoMatthew HayesKeyang YuMcKenna LosbyCarissa S HamptonChristiana M AdeyemiSeok Jae HongEleni NasiotisChen FuTae Gyu OhWeiwei FanMichael DownesRyan D WelchRonald M EvansAleksandar MilosavljevicJohn K WalkerBrian C JensenLiming PeiThomas BurrisLilei ZhangPublished in: Circulation (2023)
ERR agonists maintain oxidative metabolism, which confers cardiac protection against pressure overload-induced HF in vivo. Our results provide direct pharmacologic evidence supporting the further development of ERR agonists as novel HF therapeutics.