Resorcylic Acid Lactones from an Ilyonectria sp.
Jia ZhouYing GaoJin-Ling ChangHeng-Yi YuJuan ChenMing ZhouXiang-Gao MengHan-Li RuanPublished in: Journal of natural products (2020)
Twelve new resorcylic acid lactones (RALs) including three new 16-membered RALs (1a, 1b and 2), eight new 14-membered RALs (3-10), and one new 12-membered RAL (11), along with five known 14-membered RALs (12-16), were identified from the fermentation of the soil-derived fungus Ilyonectria sp. sb65. Their structures were established by detailed analyses of 1D and 2D NMR, HRESIMS, and X-ray diffraction crystallography. All new compounds were evaluated for their cytotoxic effects against three human cancer cell lines, along with their potential as TRAIL sensitizers in TRAIL-resistant A549 human lung adenocarcinoma cells and their in vitro immunosuppressive effects against ConA-induced T-cell and LPS-induced B-cell proliferation.
Keyphrases
- lps induced
- endothelial cells
- cell proliferation
- high resolution
- inflammatory response
- high glucose
- induced apoptosis
- induced pluripotent stem cells
- pluripotent stem cells
- magnetic resonance
- computed tomography
- cell cycle
- oxidative stress
- diabetic rats
- young adults
- risk assessment
- drug induced
- human health
- electron microscopy
- dual energy