Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes.
Simona CasiniGerard A MarchalMakiri KawasakiFransisca A NariswariVincent PorteroNicoline W E van den BergKaomei GuanAntoine H G DriessenMarieke W VeldkampIsabella MengarelliJoris R de GrootArie O VerkerkCarol Ann RemmePublished in: Cardiovascular drugs and therapy (2020)
We here demonstrate the absence of functional NaV1.8 channels in non-diseased atrial and ventricular CMs. Hence, the association of SCN10A variants with cardiac electrophysiology observed in, e.g. genome wide association studies, is likely the result of indirect effects on SCN5A expression and/or NaV1.8 activity in cell types other than CMs.