Natural Products as Regulators against Matrix Metalloproteinases for the Treatment of Cancer.
Md Towhedul IslamNak Han JangHyuck Jin LeePublished in: Biomedicines (2024)
Cancers are currently the major cause of mortality in the world. According to previous studies, matrix metalloproteinases (MMPs) have an impact on tumor cell proliferation, which could lead to the onset and progression of cancers. Therefore, regulating the expression and activity of MMPs, especially MMP-2 and MMP-9, could be a promising strategy to reduce the risk of cancers. Various studies have tried to investigate and understand the pathophysiology of cancers to suggest potent treatments. In this review, we summarize how natural products from marine organisms and plants, as regulators of MMP-2 and MMP-9 expression and enzymatic activity, can operate as potent anticancer agents.
Keyphrases
- poor prognosis
- cell proliferation
- cell migration
- transcription factor
- childhood cancer
- papillary thyroid
- binding protein
- type diabetes
- risk factors
- cardiovascular disease
- cardiovascular events
- cell cycle
- long non coding rna
- combination therapy
- nitric oxide
- squamous cell
- signaling pathway
- anti inflammatory
- smoking cessation