Locus-level antagonistic selection shaped the polygenic architecture of human complex diseases.
Weicheng SongKai YuanZhe LiuWenxiang CaiJue ChenShunying YuMin ZhaoGuan Ning LinPublished in: Human genetics (2022)
We conclude that antagonistic pleiotropy is widespread among human polygenic diseases, and it has distorted the evolutionary signal and genetic architecture of diseases at the locus level.