Briefly, PM10 exposure reduced the viability of primary cells and triggered an inflammatory response, involving NLRP3 inflammasome activation and the subsequent production of IL-1β. Moreover, PM10 induces the recruitment of cells to the lung and the expression of multiple cytokines; this phenomenon could contribute to epithelial damage and, thus to the development and exacerbation of respiratory diseases such as viral infections.
Keyphrases
- particulate matter
- air pollution
- inflammatory response
- nlrp inflammasome
- induced apoptosis
- cell cycle arrest
- chronic obstructive pulmonary disease
- heavy metals
- sars cov
- poor prognosis
- lps induced
- toll like receptor
- molecular dynamics simulations
- molecular dynamics
- risk assessment
- polycyclic aromatic hydrocarbons
- extracorporeal membrane oxygenation
- long non coding rna
- mechanical ventilation