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Monoallelic expression in melanoma.

Lee SilcockHakeem AlmabraziYounes MokrabPuthen JitheshMuna Al-HashmiNicola JamesRebecca MathewValentina MatteiDavide BedognettiFrancesca LessiRamzi TemanniBarbara SeligerRashid Al-AliFrancesco M MarincolaEna WangSara Tomei
Published in: Journal of translational medicine (2019)
The biological implications of MAE are yet to be realized. Nevertheless, our findings suggest that MAE is a common phenomenon in melanoma cell lines. Further analyses are currently being undertaken to evaluate whether MAE is gene/pathway specific and to understand whether MAE can be employed by cancers to achieve a more aggressive phenotype.
Keyphrases
  • poor prognosis
  • skin cancer
  • copy number
  • genome wide