Monoallelic expression in melanoma.
Lee SilcockHakeem AlmabraziYounes MokrabPuthen JitheshMuna Al-HashmiNicola JamesRebecca MathewValentina MatteiDavide BedognettiFrancesca LessiRamzi TemanniBarbara SeligerRashid Al-AliFrancesco M MarincolaEna WangSara TomeiPublished in: Journal of translational medicine (2019)
The biological implications of MAE are yet to be realized. Nevertheless, our findings suggest that MAE is a common phenomenon in melanoma cell lines. Further analyses are currently being undertaken to evaluate whether MAE is gene/pathway specific and to understand whether MAE can be employed by cancers to achieve a more aggressive phenotype.