Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review.
Sandra López-VerdínJesús Lavalle-CarrascoRamón G Carreón-BurciagaNicolás Addiel Serafín-HigueraNelly Molina-FrecheroRogelio González GonzálezRonell Eduardo Bologna-MolinaPublished in: Cancers (2018)
This manuscript provides an update to the literature on molecules with roles in tumor resistance therapy in head and neck squamous cell carcinoma (HNSCC). Although significant improvements have been made in the treatment for head and neck squamous cell carcinoma, physicians face yet another challenge-that of preserving oral functions, which involves the use of multidisciplinary therapies, such as multiple chemotherapies (CT) and radiotherapy (RT). Designing personalized therapeutic options requires the study of genes involved in drug resistance. This review provides an overview of the molecules that have been linked to resistance to chemotherapy in HNSCC, including the family of ATP-binding cassette transporters (ABCs), nucleotide excision repair/base excision repair (NER/BER) enzymatic complexes (which act on nonspecific DNA lesions generated by gamma and ultraviolet radiation by cross-linking and forming intra/interchain chemical adducts), cisplatin (a chemotherapeutic agent that causes DNA damage and induces apoptosis, which is a paradox because its effectiveness is based on the integrity of the genes involved in apoptotic signaling pathways), and cetuximab, including a discussion of the genes involved in the cell cycle and the proliferation of possible markers that confer resistance to cetuximab.
Keyphrases
- cell cycle
- locally advanced
- dna damage
- signaling pathway
- systematic review
- cell proliferation
- randomized controlled trial
- early stage
- primary care
- radiation therapy
- cell death
- oxidative stress
- rectal cancer
- squamous cell carcinoma
- single molecule
- computed tomography
- radiation induced
- stem cells
- epithelial mesenchymal transition
- circulating tumor
- hydrogen peroxide
- magnetic resonance
- metastatic colorectal cancer
- magnetic resonance imaging
- mesenchymal stem cells
- transcription factor
- anti inflammatory
- contrast enhanced
- combination therapy
- dna binding
- pi k akt
- bone marrow
- replacement therapy
- nitric oxide