PTEN expression as a predictor for the response to trastuzumab-based therapy in Her-2 overexpressing metastatic breast cancer.

Daphne Gschwantler-KaulichYen Y TanEva-Maria FuchsGernot HudelistWolfgang J KöstlerAngelika ReinerCarmen LeserMohamed SalamaJohannes AttemsChristine DeutschmannChristoph C ZielinskiChristian F Singer

Published in: PloS one (2017)

In Her-2-positive metastatic breast cancers, PTEN positivity was significantly associated with progressive disease, but not with PFS or OS.

Keyphrases

metastatic breast cancer
pi k akt
cell proliferation
poor prognosis
multiple sclerosis
squamous cell carcinoma
small cell lung cancer
signaling pathway
binding protein
long non coding rna
stem cells
cell therapy
young adults
bone marrow