Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review.
Monica Suet Ying NgAngela Suet Yeung NgJessica ChanJohn-Paul TungJohn Francis FraserPublished in: Intensive care medicine (2015)
Although literature presents a concerning picture of potential storage complications, current findings are too inconsistent to drive changes in clinical practice. Results from current RCTs will likely play a role in PRBC age guidelines for cardiac surgery and ICU patients. However, these studies may be less efficacious at detecting small effects that are limited to specific subpopulations.
Keyphrases
- systematic review
- cardiac surgery
- red blood cell
- clinical practice
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- acute kidney injury
- intensive care unit
- meta analyses
- peritoneal dialysis
- prognostic factors
- risk factors
- randomized controlled trial
- risk assessment
- climate change
- sickle cell disease
- patient reported