Latilactobacillus sakei Wikim0066 Protects Skin through MMP Regulation on UVB-Irradiated In Vitro and In Vivo Model.
Jeong-Yong ParkJi Yeon LeeYong Gyeong KimChang Ho KangPublished in: Nutrients (2023)
Ultraviolet (UV) B exposure induces wrinkle formation, collagen fiber breakdown, and transepidermal water loss (TEWL). UVB irradiation induces the expression of mitogen-activated protein kinase (MAPK), activator protein 1 (AP-1), and nuclear factor kappa B (NF-κB), which affect the expression of matrix metalloproteinases (MMP). We confirmed the effects of Latilactobacillus sakei wikim0066 (wikim0066) on UVB-irradiated Hs68 cells and HR-1 hairless mice cells. wikim0066 restored the production of type I procollagen by regulating the expression of MMP-1 and -3, MAPK, AP-1, and NF-κB in UVB-irradiated Hs68 cells and HR-1 mice. Oral administration of wikim0066 alleviates wrinkle formation, epidermal thickness, and TEWL in UVB-irradiated HR-1 hairless mice. These results indicated that wikim0066 has the potential to prevent UVB-induced wrinkle formation.
Keyphrases
- nuclear factor
- induced apoptosis
- signaling pathway
- cell cycle arrest
- poor prognosis
- toll like receptor
- pi k akt
- oxidative stress
- transcription factor
- type diabetes
- lps induced
- cell death
- inflammatory response
- metabolic syndrome
- small molecule
- cell migration
- skeletal muscle
- cell proliferation
- tyrosine kinase
- radiation therapy
- soft tissue
- insulin resistance
- endothelial cells
- stress induced