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The p52 isoform of SHC1 is a key driver of breast cancer initiation.

Kevin D WrightBradley S MillerSarah El-MeanawyShirng-Wern TsaihAnjishnu BanerjeeAron M GeurtsYuri SheininYunguang SunBalaraman KalyanaramanHallgeir RuiMichael J FlisterAndrey Sorokin
Published in: Breast cancer research : BCR (2019)
Collectively, these data demonstrate the p52SHC isoform is the key driver of DMBA-induced breast cancer while the expression of p66SHC and p46SHC are not enough to compensate.
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