The p52 isoform of SHC1 is a key driver of breast cancer initiation.
Kevin D WrightBradley S MillerSarah El-MeanawyShirng-Wern TsaihAnjishnu BanerjeeAron M GeurtsYuri SheininYunguang SunBalaraman KalyanaramanHallgeir RuiMichael J FlisterAndrey SorokinPublished in: Breast cancer research : BCR (2019)
Collectively, these data demonstrate the p52SHC isoform is the key driver of DMBA-induced breast cancer while the expression of p66SHC and p46SHC are not enough to compensate.