Prospective validation study of prognostic biomarkers to predict adverse outcomes in patients with COVID-19: a study protocol.

Benjamin TangMaryam ShojaeiYa WangMarek NalosAnthony McleanAli AfrasiabiTim N KwanWin Sen KuanYoann ZerbibVelma HerwantoGunawan GunawanDavide BedognettiGabriele ZoppoliAlberto BallestreroDarawan RinchaiPaolo CremonesiMichele BedognettiMartin MatejovicThomas KarvunidisStephen P J MacdonaldAmanda J CoxNicholas P WestAllan William CrippsKlaus SchughartAndrea de MariaDamien ChaussabelJonathan IredellStephen Wengnull null

Published in: BMJ open (2021)

This research protocol aims to study the host response gene expression biomarkers in severe respiratory viral infections with a pandemic potential (COVID-19). It has been approved by the local ethics committee with approval number 2020/ETH00886. The results of this project will be disseminated in international peer-reviewed scientific journals.

Keyphrases

sars cov
coronavirus disease
gene expression
randomized controlled trial
study protocol
public health
dna methylation
respiratory syndrome coronavirus
clinical trial
quality improvement
big data
machine learning
open label
human health
deep learning
double blind