Comprehensive gene expression profiling identifies distinct and overlapping transcriptional profiles in non-specific interstitial pneumonia and idiopathic pulmonary fibrosis.
Matthew J CecchiniKarishma HoseinChristopher J HowlettMariamma JosephMarco MuraPublished in: Respiratory research (2018)
Comprehensive gene expression profiling in explanted lungs identifies distinct transcriptional profiles and differentially expressed genes in IPF and NSIP, supporting the notion of NSIP as a standalone condition. Potential gene and protein markers to discriminate IPF from NSIP were identified, with a prominent role of senescence in IPF. The finding of a subgroup of IPF patients with transcriptional features of both NSIP and senescence raises the hypothesis that "senescent" NSIP may represent a risk factor to develop superimposed IPF.
Keyphrases
- idiopathic pulmonary fibrosis
- gene expression
- genome wide
- dna methylation
- interstitial lung disease
- transcription factor
- dna damage
- risk factors
- single cell
- endothelial cells
- genome wide identification
- copy number
- risk assessment
- stress induced
- randomized controlled trial
- heat shock
- binding protein
- oxidative stress
- small molecule
- human health
- rheumatoid arthritis
- heat shock protein