Reduced hydroxymethylation characterizes medulloblastoma while TET and IDH genes are differentially expressed within molecular subgroups.
Karina Bezerra SalomãoGustavo Alencastro Veiga CruzeiroRicardo Bonfim-SilvaLenisa GeronFernando RamalhoFabiano Pinto SaggioroLuciano Neder SerafiniDaniel Antunes MorenoRosane Gomes de Paula QueirozSimone Dos Santos AguiarIzilda CardinalliJosé Andres YunesSilvia Regina BrandaliseMaria Sol BrassescoCarlos Alberto ScrideliLuiz Gonzaga TonePublished in: Journal of neuro-oncology (2018)
These findings suggest that reduction of global hydroxymethylation levels, an epigenetic event, may be important for MB development and/or maintenance, representing a possible target in this tumour and indicating a possible interaction of TET and IDH genes with the developmental pathways specifically activated in the MB subgroups. These genes could be specific targets and markers for each subgroup.