Microcapsules loaded with date seed extract and its inhibitory potential to modulate the toxic effects of mycotoxins in mice received mold-contaminated diet.
Sogand SaneiMohammadamin Bozorgi KasgariFatemeh AbedinzadehAtena Poor SasanSaeid HassaniEhsan KarimiEhsan OskoueianMohammad Faseleh JahromiPublished in: Environmental science and pollution research international (2023)
Mycotoxins are the secondary fungal metabolites generally produced by wide range of fungi including aflatoxins (AF), ochratoxin A (OTA), fumonisins (FB), zearalenone (ZEN), and deoxynivalenol (DON). Nowadays, they are main concern to food and agricultural commodities due to undesirable health and socio-economic effect. This investigation was designed to synthesized microcapsules loaded the bioactive compounds of date seed and evaluated its inhibitory activities in mice received mold-contaminated diet. The finding revealed that the developed microcapsule is homogenous and mostly spherical with size of 2.58 μm with acceptable PDI of 0.21. The main phytochemical has been confirmed by HPLC analysis were xylose, fructose, mannose, glucose, and galactose with the respective values of 41.95%, 2.24%, 5.27%, and 0.169%. The in vivo analyses manifested that the mice received date seed microcapsules significantly (p < 0.05) improved the average daily weight gain, feed intake, liver enzymes (ALT, ALP, and AST), and lipid peroxidation values compare to mice group received mycotoxin-contaminated diet. Furthermore, encapsulation date seed bioactive compounds notably up-regulated the expression of GPx, SOD, IFN-γ, and IL-2 genes while down-regulated the iNOS gene. Consequently, the novel microcapsules loaded date seed is suggested to be considered as a promising mycotoxin inhibitor.
Keyphrases
- weight gain
- heavy metals
- high fat diet induced
- physical activity
- drug delivery
- weight loss
- ms ms
- body mass index
- drinking water
- cancer therapy
- human health
- healthcare
- transcription factor
- immune response
- poor prognosis
- atrial fibrillation
- dendritic cells
- birth weight
- genome wide
- type diabetes
- gene expression
- metabolic syndrome
- wild type
- climate change
- copy number
- dna methylation
- data analysis
- simultaneous determination
- adipose tissue
- nitric oxide synthase
- health promotion
- long non coding rna