Randomized phase III study of high-dose methotrexate and whole-brain radiotherapy with/without temozolomide for newly diagnosed primary CNS lymphoma: JCOG1114C.
Kazuhiko MishimaRyo NishikawaYoshitaka NaritaJunki MizusawaMinako SumiTomoyuki KogaNobuyoshi SasakiManabu KinoshitaMotoo NaganeYoshiki ArakawaKoji YoshimotoIchiyo ShibaharaNaoki ShinojimaKenichiro AsanoTakao TsurubuchiHikaru SasakiAkio AsaiTakashi SasayamaYasutomo MomiiAtsushi SasakiShigeo NakamuraMasaru KojimaJunichi TamaruKazuhiro TsuchiyaMiho GomyoKayoko AbeManabu NatsumedaFumiyuki YamasakiHiroshi KatayamaHaruhiko FukudaPublished in: Neuro-oncology (2022)
This study failed to demonstrate the benefit of concomitant and maintenance TMZ in newly diagnosed PCNSL.