A novel experimental model of erectile dysfunction in rats with heart failure using volume overload.

Fábio Henrique SilvaFrederico José Reis VeigaAline Gonçalves MoraRodrigo Sader HeckCaroline Candida De OliveiraAlessandra GamberoCarla Fernanda Franco-PenteadoEdson AntunesJason D GardnerFernanda Bruschi Marinho PrivieroMário Angelo Claudino

Published in: PloS one (2017)

ED in HF rats is associated with decreased NO bioavailability in erectile tissue due to eNOS/nNOS dowregulation and NOX2 upregulation, as well as hypercontractility of the penis. This rat model of ACF could be a useful tool to evaluate the molecular alterations of ED associated with HF.

Keyphrases

heart failure
emergency department
acute heart failure
nitric oxide synthase
cell proliferation
poor prognosis
signaling pathway
nitric oxide
atrial fibrillation
benign prostatic hyperplasia