Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.
Richard J PackerNick ShrineRobert HallCarl A MelbourneRebecca ThompsonAlex T WilliamsMegan L PayntonAnna L GuyattRichard J AllenPaul Hong LeeCatherine JohnArchie CampbellCaroline HaywardMaaike M De VriesJudith E VonkJonathan DavitteEdith M HesselDavid MichalovichJoanna C BettsIan SayersAstrid YeoIan P HallMartin D TobinLouise V WainPublished in: The European respiratory journal (2023)
and mucin loci suggest that mucin fucosylation may be a driver of chronic sputum production even in the absence of diagnosed respiratory disease and provide genetic support for this pathway as a target for therapeutic intervention.