Effects of bromodomain and extra-terminal inhibitor JQ1 and interleukin-6 on breast cancer cells.

Atefeh SharifhoseiniMasoud HeshmatiAmin SoltaniMahshad EntezamHedayatollah ShirzadMorteza SedehiBabri A JuddMohammad-Saeid JamiMahdi Ghatrehsamani

Published in: Molecular biology reports (2023)

Analysis of gene expression indicated that JQ1 and IL-6 synergistically increase SNAIL expression and decrease c-MYC expression in MCF-7 cells. So, the BET proteins are promising, novel therapeutic targets in late-stage breast cancers. BET inhibitors similar to JQ1 show promise as therapeutic candidates for breast cancers, especially when triple-negative breast cancer cells are increased and/or tumor-promoting factors like IL-6 exist in the tumor microenvironment.

Keyphrases

breast cancer cells
gene expression
poor prognosis
induced apoptosis
epithelial mesenchymal transition
dna methylation
binding protein
cell cycle arrest
oxidative stress
machine learning
endoplasmic reticulum stress
cell proliferation