Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.

Aim: The roles of circular RNA (circRNA) in tumor development are not fully understood. This study aims to explore the possible role of circRNAs as drug targets for the treatment of cervical squamous cell carcinoma (CSCC). Materials & methods: Through the bioinformatics approach to integrating multiple types of gene expression profiles, a circRNA-centered gene regulatory network was generated to explore the role of circRNAs in CSCC. Results: The expression levels of hsa_circ_0043280 and hsa_circ_0027821 were significantly different in tissues and might function as competing endogenous RNAs and play vital roles in CSCC development. Conclusion: We constructed a regulatory network consisting of two circRNAs, two miRNAs, 22 mRNAs and 19 drugs/chemicals and provided new insight into the prognosis and therapy of CSCC.