Cellular membrane-targeting ruthenium complexes as efficient photosensitizers for broad-spectrum antibacterial activity.
Yi WangYa-Tao HuHai-Lin ZhangYu-Yu ChenHong-Dong ShiJin-Gang LiuQian-Ling ZhangPublished in: Dalton transactions (Cambridge, England : 2003) (2023)
A ruthenium complex [Ru(phen) 2 (phen-5-amine)-C14] (Ru-C14) with broad-spectrum antibacterial activity was designed and synthesized; positively charged Ru-C14 could target bacteria via electrostatic interactions and showed high binding effectiveness to cell membranes. In addition, Ru-C14 could act as a photosensitizer. Under 465 nm light irradiation, Ru-C14 could generate 1 O 2 , thus disrupting the bacterial intracellular redox balance and leading to bacterial death. Ru-C14 also exhibited minimum inhibitory concentration values of 6.25 μM against Escherichia coli and 3.125 μM against Staphylococcus aureus ; these values are lower than those of streptomycin and methicillin. This work combined the merits of cell membrane targeting and photodynamic therapy for antibacterial activity. The findings might open up a new avenue for effective anti-infection treatment and other medical applications.
Keyphrases
- staphylococcus aureus
- energy transfer
- photodynamic therapy
- escherichia coli
- cancer therapy
- systematic review
- randomized controlled trial
- minimally invasive
- biofilm formation
- radiation therapy
- methicillin resistant staphylococcus aureus
- binding protein
- reactive oxygen species
- mesenchymal stem cells
- klebsiella pneumoniae
- radiation induced
- transcription factor
- replacement therapy