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Comparison of Drug Use Between Clinical Practice and Regulatory Approval: Results in Older Japanese Patients With Rheumatoid Arthritis, Diabetes, High Blood Pressure, or Depression.

Nanae TanemuraYoshiaki UyamaKengo NagashimaTakahiro SuzukiYasuko AsahinaYoshio KobayashiMasaomi IyoKoutaro YokoteHideki Hanaoka
Published in: Therapeutic innovation & regulatory science (2016)
Appropriate doses of drugs for older patients may differ from approved doses in certain diseases. Complex situations such as a lot of polypharmacy, comorbidity, and functional impairment in older patients in clinical practice make it difficult to evaluate safety based on data from clinical trials. In the future, utilization of a database created from the EMR of older patients should be considered for assessment of drug safety in older patients in clinical practice.
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