Comparison of Drug Use Between Clinical Practice and Regulatory Approval: Results in Older Japanese Patients With Rheumatoid Arthritis, Diabetes, High Blood Pressure, or Depression.
Nanae TanemuraYoshiaki UyamaKengo NagashimaTakahiro SuzukiYasuko AsahinaYoshio KobayashiMasaomi IyoKoutaro YokoteHideki HanaokaPublished in: Therapeutic innovation & regulatory science (2016)
Appropriate doses of drugs for older patients may differ from approved doses in certain diseases. Complex situations such as a lot of polypharmacy, comorbidity, and functional impairment in older patients in clinical practice make it difficult to evaluate safety based on data from clinical trials. In the future, utilization of a database created from the EMR of older patients should be considered for assessment of drug safety in older patients in clinical practice.
Keyphrases
- clinical practice
- blood pressure
- clinical trial
- type diabetes
- adverse drug
- cardiovascular disease
- physical activity
- depressive symptoms
- electronic health record
- emergency department
- transcription factor
- randomized controlled trial
- heart rate
- machine learning
- adipose tissue
- sleep quality
- metabolic syndrome
- drug induced
- glycemic control
- blood glucose
- data analysis