A Study of Through-Space and Through-Bond JPP Coupling in a Rigid Nonsymmetrical Bis(phosphine) and Its Metal Complexes.
Brian A ChalmersPhillip S NejmanAlice V LlewellynAdrian M FelaarBen L GriffithsEden I PortmanEmma-Jane L GordonKenny J H FanJ Derek WoollinsM BühlOlga L MalkinaDavid Bradford CordesAlexandra M Z SlawinPetr KilianPublished in: Inorganic chemistry (2018)
A series of representative late d-block metal complexes bearing a rigid bis(phosphine) ligand, iPr2P-Ace-PPh2 (L, Ace = acenaphthene-5,6-diyl), was prepared and fully characterized by various techniques, including multinuclear NMR and single-crystal X-ray diffraction. The heteroleptic nature of the peri-substituted ligand L allows for the direct observation of the JPP couplings in the 31P{1H} NMR spectra. Magnitudes of JPP are correlated with the identity and geometry of the metal and the distortions of the ligand L. The forced overlap of the phosphine lone pairs due to the constraints imposed by the rigid acenaphthene skeleton in L results in a large 4 JPP of 180 Hz. Sequestration of the lone pairs, either via oxidation of the phosphine or via metal chelation, results in distinct changes in the magnitude of JPP. For tetrahedral d10 complexes ([LMCl2], M = Zn, Cd, Hg), the JPP is comparable to or larger than (193-309 Hz) that in free ligand L, although the P···P separation in these complexes is increased by ca. 0.4 Å (compare to free ligand L). The magnitude of JPP diminishes to 26-117 Hz in square planar d8 complexes ([LMX2], M = Ni, Pd, Pt; X = Cl, Br) and the octahedral Mo0 complex ([LMo(CO)4], 33 Hz). Coupling deformation density calculations indicate the through-space interaction dominates in free L, while in metal complexes the main coupling pathway is via the metal atom.
Keyphrases
- high resolution
- magnetic resonance
- room temperature
- molecular dynamics
- angiotensin ii
- density functional theory
- cross sectional
- molecular dynamics simulations
- magnetic resonance imaging
- angiotensin converting enzyme
- solid state
- hydrogen peroxide
- nitric oxide
- risk assessment
- mass spectrometry
- molecular docking
- protein kinase