The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways.
Anindita TripathySudhir ThakurelaManoj Kumar SahuKanishka UthanasinghManas BeheraAmrendra Kumar AjayRatna KumariPublished in: PloS one (2018)
Our data uncovers the grade related expression of Wnt and Hh pathway molecules and the potential utility of these molecular signatures in daily clinical practice is to decide best therapy according to patients characteristic. Additionally, our data offer insight into the interaction between Wnt and Hh pathways which triggers HCC development and progression.
Keyphrases
- cell proliferation
- stem cells
- clinical practice
- end stage renal disease
- electronic health record
- ejection fraction
- newly diagnosed
- signaling pathway
- poor prognosis
- chronic kidney disease
- big data
- prognostic factors
- physical activity
- single molecule
- mesenchymal stem cells
- pi k akt
- genome wide
- epithelial mesenchymal transition
- machine learning
- risk assessment
- oxidative stress
- bone marrow
- data analysis
- binding protein
- drug induced
- replacement therapy
- induced apoptosis
- artificial intelligence